Erythropoietin-driven dynamic proteome adaptations during

In the absence of the Epo receptor (EpoR) in embryos, we observe a lack of hemoglobin in CFU-E cells and massive iron overload of the fetal liver pointing to a miscommunication between liver and placenta. ... This link connecting erythropoiesis with the regulation of iron homeostasis and metabolic reprogramming suggests that balancing these ...

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Iron Loading and Overloading due to Ineffective Erythropoiesis

In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion.

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Effects of Exogenous Transferrin on the Regulation of Iron …

Effects of Exogenous Transferrin on the Regulation of Iron Metabolism and Erythropoiesis in Iron Deficiency With or Without Anemia Front Physiol. 2022 May 11:13:893149. doi: 10.3389 ... by pronounced decreases in serum and tissue iron concentrations, and an increase in serum erythropoietin. In the absence of exogenous holoTf, ...

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Dysregulated iron metabolism in polycythemia vera: etiology …

Iron deficiency is defined by insufficient iron availability to meet physiological needs in the presence or absence of anemia. Because >60% of the body's iron is found within hemoglobin, and ...

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Erythropoiesis: The Roles of Erythropoietin and Iron

Erythropoietin (EPO) is the key hormone responsible for effective erythropoiesis, and iron is the essential mineral required for hemoglobin production. EPO allows survival and …

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Ineffective erythropoiesis associated with iron overload in absence …

This iron overload is due to ineffective erythropoiesis, similar to what occurs in congenital dyserythropoietic anemias, thalassemia, and anemias with decreased hepcidin and increased intestinal ...

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Macrophages and iron trafficking at the birth and death of …

Humans with mutations leading to the absence of transferrin suffer from hypochromic microcytic anemias. Without the delivery of transferrin-bound iron, erythroid precursors lack sufficient iron to support heme and hemoglobin synthesis. ... As previously mentioned, the majority of iron required to sustain erythropoiesis is derived from recycled ...

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Iron metabolism under conditions of ineffective erythropoiesis in …

Intestinal hypoxia-inducible factor 2α (HIF2α) is an important contributor to iron absorption under conditions of iron deficiency, erythropoiesis, and hepcidin deficiency. 13, 14 HIF2α belongs to the family of hypoxia-inducible transcription factors, which control the cellular and systemic responses to oxygen deficiency. 15 Ferroportin, as well as other iron-related …

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The mutual control of iron and erythropoiesis

ineffective erythropoiesis: iron restr iction reduces heme and alpha-globin synthesis that may be of benefit in thalassemia. ... while in the absence of ane-mia, <1–2 mg iron daily derives from intestinal absorption. Classic iron studies have clarified the molecular mechanisms underlying iron absorption, transport in

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Chapter 2 INEFFECTIVE ERYTHROPIESIS AND ANAEMIA

In non-transfusion-dependent β-thalassemia (NTDT), erythropoiesis is ineffective due to the imbalance in the production of α- and β-globin chains. Unstable globin chain tetramers …

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Ineffective Erythropoiesis, Anemia and Iron Overload

Current understanding of iron homeostasis and its dysregulation warrants a two-pronged approach at combating iron overload under conditions of ineffective erythropoiesis. The first …

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Effects of Exogenous Transferrin on the Regulation of Iron …

relationship between iron status and erythropoiesis in the absence. of other pathologic confounders. ... However, iron depleted erythropoiesis is incompletely understood. In this study, an ex vivo ...

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Detection, evaluation, and management of iron-restricted erythropoiesis

Progress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. ... This analysis suggests that in the absence of a ...

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Detection, evaluation, and management of iron …

Iron-restricted erythropoiesis can develop from a variety of causes. Absolute iron deficiency anemia can result from low dietary iron content, impaired iron absorption, or excessive iron loss (bleeding), but in these conditions, iron …

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Normal and dysregulated crosstalk between iron …

The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for …

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Definition of functional iron deficiency and intravenous iron

Iron-restricted erythropoiesis occurs in cases of both absolute and functional iron deficiency.

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Definition of functional iron deficiency and intravenous iron

Iron-restricted erythropoiesis occurs in cases of both absolute and functional iron deficiency. The latter setting represents a state of iron-restricted erythropoiesis characterised by an imbalance between iron demand and serum iron that is readily available for effective erythropoiesis.1 Anaemia associated with chronic disease is usually diagnosed in the absence of iron …

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Iron deficiency

Iron deficiency anemia affects >1.2 billions individuals worldwide, and iron deficiency in the absence of anemia is even more frequent. Total-body (absolute) iron deficiency is caused by physiologically increased iron requirements in children, adolescents, young and pregnant women, by reduced iron intake, or by pathological defective absorption or chronic blood loss.

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Red Cells, Iron, and Erythropoiesis: Enhanced erythropoiesis …

The role of macrophages in erythropoiesis and iron metabolism has long been recognized. 32 It has been suggested that interaction of macrophages with ... allowing us to assess how the absence of Hfe in the hematopoietic compartment affects erythropoiesis in the absence of iron overload. As a further control for evaluating ...

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The role of iron in erythropoiesis in the absence and …

With supplemental oral iron, the endogenous erythropoietic response to routine autologous blood donation and to the anaemia of chronic illness has been shown to be …

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Erythropoiesis: Model systems, molecular regulators, and

Iron metabolism, cellular heme and erythropoiesis are inextricably linked. The major source of iron for erythrocyte precursors is plasma iron-transferrin (Fe-Tf). When iron supply to the bone marrow is inadequate because of systemic iron deficiency or iron sequestration, iron-restricted erythropoiesis or anemia results (95, 96).

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Iron metabolism under conditions of ineffective erythropoiesis …

Anemic patients affected by BT suffer from iron overload, even in the absence of chronic blood transfusion, suggesting the presence of ≥1 erythroid factor with the ability to modulate iron metabolism and dietary iron absorption. ... In patients with TM, frequent blood transfusions suppress endogenous (ineffective) erythropoiesis, and iron ...

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Iron Loading and Overloading due to Ineffective Erythropoiesis

In the absence of blood transfusions, hereditary mutations play the primary role in most syndromes of iron overload [1]. The genetic bases for several inherited forms of …

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The role of iron in erythropoiesis in the absence and …

Studies show no difference in the degree of endogenously stimulated erythropoiesis between patients with measurable iron stores and those without. However, when treated with rHuEPO, …

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Stat5 activation enables erythropoiesis in the …

The requirement of Epo signaling pathway components for erythropoiesis is evident from mice deficient for Epo, EpoR, or Jak2. All mutant animals die in utero at embryonic day 13.5 (E13.5) because of a failure of …

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Recommendations for diagnosis, treatment, and prevention of iron

In patients with functional ID, withholding iron from the plasma promotes iron‐deficient erythropoiesis and anemia despite adequate body iron stores. 14, 15 This process is common in patients with inflammation, malignancy, ... and enable personalization of the route of iron replenishment. 31 In the absence of inflammation, ...

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The role of iron in erythropoiesis in the absence and …

Download Citation | The role of iron in erythropoiesis in the absence and presence of erythropoietin therapy | Preoperative autologous blood donation has served as a model for blood loss anaemia.

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Enhanced erythropoiesis in

The role of macrophages in erythropoiesis and iron metabolism has long been recognized. 32 ... allowing us to assess how the absence of Hfe in the hematopoietic compartment affects erythropoiesis in the absence of iron overload. As a further control for evaluating erythropoiesis in mice developing iron overload, ...

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